Keynote - Skeletal Muscle with Aging, and Physical Activity
نویسندگان
چکیده
منابع مشابه
Skeletal muscle aging: influence of oxidative stress and physical exercise
Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencie...
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Skeletal muscle has the ability to adapt and remodel after functional, mechanical, and metabolic stresses by activation of different adaptation mechanisms that induce gene expression, biochemical changes, and structural remodeling. Skeletal muscle cells continuously generate reactive oxygen and nitrogen species (RONS), which can act as mediators in cellular signaling pathways that regulate the ...
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Physical activities are associated with increased production of reactive oxygen species. The production of reactive oxygen species is dependent of the intensity, duration and type of activity. Although the physiological amounts of reactive oxygen species are necessary to regulate cell reactions, their excessive production can cause numerous damages to the structure and function of cells and wea...
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Sarcopenia may be partly due to a loss in total fiber number by apoptosis. We have investigated age-related alterations in the mitochondria-mediated pathway leading to apoptosis in the gastrocnemius muscle from 6-mo-old and 24-mo-old male Fisher 344 rats. Apoptosis (mono- and oligonucleosome fragmentation) in the gastrocnemius muscle was increased by 50% in the old rats compared with the adult ...
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Lipoprotein lipase (LPL) is a key enzyme for fatty acid and lipoprotein metabolism in muscle. However, the effect of aging on LPL regulation in skeletal muscle is unknown. We report the effect of aging on LPL regulation in the soleus (red oxidative postural) muscle and the tibialis anterior (white glycolytic non-weight-bearing) muscle in 4- and 24-mo-old Fischer 344 rats and 18- and 31-mo-old F...
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ژورنال
عنوان ژورنال: Medicine & Science in Sports & Exercise
سال: 2020
ISSN: 1530-0315,0195-9131
DOI: 10.1249/01.mss.0000679432.97771.f7